PAWPAW THERAPY
PAW PAW EXTRACT AS A NATURAL CANCER TREATMENT
http://alternativecancer.us/pawpaw.htm
Paw Paw extract contains (among other active ingredients) acetogenins which modulate the production of ATP** (adenosine triphosphate) in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.
Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.
Multiple Drug Resistant Cells
Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, do not show up in scans. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively gone (gone where is something to consider). However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will disapear because they are all MDR. Paw Paw and Graviola are the only cancer treatments that have shown effectiveness against MDR cells.
Development
Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufacture Paw Paw twig extract in capsule form.
Pharmacology
One of the effects of Paw Paw is to reduce the ATP energy in each cell of our body. Our cells have an electrical potential that effects how the cell processes energy producing substances mostly blood sugar and oxygen from our blood supply (the red area in the graphic below).
By reducing this voltage level from 70 to 110 mv to something in the 50 mv region, normal cells can still function. However, cancer and viral cells cannot process energy at this low voltage level and start to starve. The process of starving is a slower process than being poisoned which is why Paw Paw works slower than chemo. When Paw Paw does not work, it is usually because it is not absorbed sufficiently into the cells of the body to cause this voltage reduction.
Blood Brain Barrier
Paw Paw is one of the few alternative cancer treatments that can pass the blood/brain barrier. The other alternative cancer treatments that can cross this barrier are Cantron and Protocel.
Effectiveness
Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell (Cantron and Protocel) works and Cancell also has a 50% effectiveness as demonstrated in another informal study. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth of MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University.
Studies
Here are a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:
ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.
ABSTRACT: Journal of Medicinal Chemistry 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.
Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.
Additional Paw Paw research papers can be see at PawPawResearch.com
Quantity of Papers
There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.
Paw Paw and Viruses
ATP is a direct and indirect precursor of DNA and RNA. This can slow or stop viral reproduction for viruses such as cold sores and shingles. Although the test results below show encouraging antiviral effect, it seems that Cancell (Cantron and Protocel) has a stronger antiviral effect. On the other hand Paw Paw has shown anecdotal evidence of being a strong anti-bacterial agent.
Considering the performance of Paw Paw in a study of 94 terminal cancer patients and its performance against MDR cells, it seems that Paw Paw would stand alone as a cancer treatment very well.
Dosage and Ease of Use
Paw Paw is easy to use. You only need two capsules, three times day, and taken with some food.
People who change their eating habits greatly increase the effectiveness of the supplements they take., especially regarding getting the cellular pH in into the alkaline range.
Regardless of treatment, recovery is much more likely if the emotional component
is addressed. Visit the Tapping DVD page to learn about the simplest and
most effective method to remove emotional bocks to your healing.
Side Effects
Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.
Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.
Cantron or Protocel and Paw Paw
You can take Protocel with Paw Paw, but don't forget to read all the Paw Paw protocols under the Dosage and Ease of Use (above) and Compatability (just below) sections. Some people respond very quickly to Cantron or Protocel. In this case the body may have excessive waste material to remove. Paw Paw can increase the response of your body and overload the waste removal system. To present this overload, some people start Paw Paw 3 to 5 weeks after starting Cantron or Protocel or starting Paw Paw before Cantron or Protocel.
You should avoid food for 15 minutes before and after taking Cantron or Protocel, but you should have some food with Paw Paw. therefore, people take the Cantron or Protocel first, wait 15 minutes, eat a little and take the PawPaw. New recommended doseage for Paw Paw is 2 capsule three times a day. Since the recommended dose for Cantron or Protocel is six times a day, you alternate taking Paw Paw with Cantron or Protocel with just taking Cantron or Protocel. For example:
6 AM Cantron or Protocel, 6:15 AM Paw Paw
10 AM Cantron or Protocel
2 PM Cantron or Protocel, 2:15 PM Paw Paw
6 PM Cantron or Protocel
10 PM Cantron or Protocel, 10:15 PM Paw Paw
2 AM Cantron or Protocel
Since Paw Paw is fat soluble it will work better after a person has started eating for the day. Therefore, some users start taking Paw Paw with the second dose of Cantron or Protocel. See the Dosage section just above.
Table of Contents | Return to the Comparison Table* | View Shopping Cart
Compatibility
Paw Paw reduce the side effects of chemo, but does not interfere with chemo.
Warning: If a cancer patient uses Paw Paw during a course of chemo, the reduced side effects caused by Paw Paw may encourage the oncologist to increase the dose of chemo. If the patient then decides to stop the Paw Paw, for whatever reason, the side effects of chemo can increase and greatly threaten the patients life.
One of the ways that Paw Paw works is to prevent cancer cells from feeding on glucose by reducing the ATP energy of the cells in our body. The substances in the following list increase ATP energy and should therefore be avoided when taking Paw Paw. Some people believe that you can take some of these things with Paw Paw because they were tested with Paw Paw and Paw Paw was still able to kill cancer cells in test tubes. However, Paw Paw works in a number of ways and those other ways may have been responsible for how Paw Paw worked with some of the things on this list.
Vitamins to Avoid when on Paw paw treatment
Vitamin C (taking vitamin C is the number one reason that Paw Paw fails to work)
Vitamin E
Selenium
Thyroid support products
SOD
CoEnzyme Q10
"sea greens" such as spirulina, algae, chlorella, kelp may have a problem
The amount of vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.
The following counter the effects of Paw Paw:
Burdock Root Essiac tea and Flor-Essence (which is similar to Essiac with a couple of extra ingredients) Ozone treatments ( oxygen treatments such as hyperbaric oxygen are beneficial to the functioning of Protocel) Flax seed oil as used in the Budwig diet (also spelled flaxseed oil). It is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution IP6 (in theory there may be a problem, but case histories are needed) 714-x Hydrogen peroxide PMB Techno Creatine Cellect Ginseng Glutamine Taurine Rhodiola Rhosea D-Ribose Magnesium In higher doses, magnesium is credited with increasing ATP production. L-Carnitine Resveratrol Colloidal silver - the heavy metal quality of silver could cause a reaction with Protocel. Pau d'arco with Germanium-132 (taking either separately with Protocel is OK) Grapefruit seed extract (due to its high vitamin C content) Whey protein should also be avoided because of the L-cysteine Iodine IGF Enercel MSM Cesium Chloride Poly-MVA because of the alpha-lipoic acid Hormone-Blocking Drugs Immunocal MMS (Miracle Mineral Supplement) chlorine dioxide Sulfhydrazly antioxidants which includes:
L-cysteine N-acetylsteine Alpha-lipoic acid Glutathion
http://alternativecancer.us/pawpaw.htm
Paw Paw extract contains (among other active ingredients) acetogenins which modulate the production of ATP** (adenosine triphosphate) in mitochondria of cancer cells. This reduces the growth of blood vessels that nourish cancer cells. It also inhibits the growth of MDR (multiple drug resistance) cells. No other alternative or conventional cancer treatment (except treatments from trees similar to Paw Paw) has shown any effectiveness against MDR cells.
Paw Paw is a cousin of the graviola, guanabana, and soursop trees. However, the acetogenins extracted from Paw Paw are more active against cancer than those extracted from these other sources.
Multiple Drug Resistant Cells
Most tumors contain a small percentage, approximately 2%, of multiple drug-resistant cells (MDR cells). Chemo is not effective against these cells. After the first round of chemo, if the chemo is effective, all of the cells that are not MDR, do not show up in scans. Since this accounts for the vast majority of the tumor mass, the tumor will appear to be effectively gone (gone where is something to consider). However, the MDR cells remain and start to multiply. Eventually, a new tumor is formed that is entirely MDR. The next time chemo is used, none of the cells will disapear because they are all MDR. Paw Paw and Graviola are the only cancer treatments that have shown effectiveness against MDR cells.
Development
Paw Paw research was performed at Purdue College by Jerry McLaughlin. The majority of the funding (20 years and about 5 million dollars) for this research was provided by NCI. Jerry McLaughlin now works with Nature Sunshine who manufacture Paw Paw twig extract in capsule form.
Pharmacology
One of the effects of Paw Paw is to reduce the ATP energy in each cell of our body. Our cells have an electrical potential that effects how the cell processes energy producing substances mostly blood sugar and oxygen from our blood supply (the red area in the graphic below).
By reducing this voltage level from 70 to 110 mv to something in the 50 mv region, normal cells can still function. However, cancer and viral cells cannot process energy at this low voltage level and start to starve. The process of starving is a slower process than being poisoned which is why Paw Paw works slower than chemo. When Paw Paw does not work, it is usually because it is not absorbed sufficiently into the cells of the body to cause this voltage reduction.
Blood Brain Barrier
Paw Paw is one of the few alternative cancer treatments that can pass the blood/brain barrier. The other alternative cancer treatments that can cross this barrier are Cantron and Protocel.
Effectiveness
Paw Paw seems to work on all types of cancers. An informal study of 100 cancer patients showed that Paw Paw was effective in half the cases. This is most interesting since Paw Paw seems to work the same way that Cancell (Cantron and Protocel) works and Cancell also has a 50% effectiveness as demonstrated in another informal study. However, Paw Paw gets higher marks in the effectiveness because, in the laboratory, it inhibits the growth of MDR (multiple drug resistance) cells. No other cancer treatment including chemo has shown any effectiveness against MDR cells. Jerry McLaughlin is in the negotiation process for starting clinical trials in conjunction with Harvard University.
Studies
Here are a few abstracts from studies conducted at Purdue University where most of the Paw Paw research for the past 30 years was conducted:
ABSTRACT: Cancer Letters 115 (1997) 73-79 The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Nicholas H. Oberlies, Vicki L. Croy, Marietta L. Harrison, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.
ABSTRACT: Journal of Medicinal Chemistry 1997, 40, 2102-2106 Structure-activity relationships of diverse Annonaceous acetogenins against multidrug-resistant human mammary adenocarcinoma (MCF-7/Adr) cells Nicholas H. Oberlies, Ching-jer Chang, Jerry L. McLaughlin Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University.
Fourteen structurally diverse Annonaceous acetogenins, representing the three main classes of bis-adjacent, bis-nonadjacent, and single-THF ring(s), were tested for their ability to inhibit the growth of adriamycin-resistant human mammary adenocarcinoma (MCF-7/Adr) cells. This cell line is resistant to treatment with adriamycin, vincristine, and vinblastine and is, thus, multidrug-resistant (MDR). Among a series of bis-adjacent THF ring acetogenins, those with the stereochemistry of threo-trans-threo-trans-erythro (from C-15 to C-24) were the most potent with as much as 250 times the potency of adriamycin. A spacing of 13 carbons between the flanking hydroxyl of the THF ring system and the gamma-unsaturated lactone seems to be optimum with a spacing of 11 and 9 carbons being significantly less active. Several single-THF ring compounds were also quite potent, with gigantetrocin A (11) being the most potent compound tested. The acetogenins may, thus, have chemotherapeutic potential, especially with regard to MDR tumors.
Copies of the journal articles mentioned in the story are available from the Purdue News Service, (765) 494-2081.
Additional Paw Paw research papers can be see at PawPawResearch.com
Quantity of Papers
There have been over 100 scientific papers published on the chemistry and biology of the paw paw compounds.
Paw Paw and Viruses
ATP is a direct and indirect precursor of DNA and RNA. This can slow or stop viral reproduction for viruses such as cold sores and shingles. Although the test results below show encouraging antiviral effect, it seems that Cancell (Cantron and Protocel) has a stronger antiviral effect. On the other hand Paw Paw has shown anecdotal evidence of being a strong anti-bacterial agent.
Considering the performance of Paw Paw in a study of 94 terminal cancer patients and its performance against MDR cells, it seems that Paw Paw would stand alone as a cancer treatment very well.
Dosage and Ease of Use
Paw Paw is easy to use. You only need two capsules, three times day, and taken with some food.
People who change their eating habits greatly increase the effectiveness of the supplements they take., especially regarding getting the cellular pH in into the alkaline range.
Regardless of treatment, recovery is much more likely if the emotional component
is addressed. Visit the Tapping DVD page to learn about the simplest and
most effective method to remove emotional bocks to your healing.
Side Effects
Paw Paw gravitates toward cells that use a lot of energy and cut off their energy supply. Since cancer cells use 10-17 times as much energy as a normal cell, Paw Paw acts on cancer cells. It is the same mechanism that made it so useful as a parasite cleanse and to kill hair lice. It is also the reason that a pregnant woman should not take it. Paw Paw could see the baby as a high energy user.
Some people with cancer have reported digestion distress such as nausea. For this reason it is recommended to take Paw Paw with food.
Cantron or Protocel and Paw Paw
You can take Protocel with Paw Paw, but don't forget to read all the Paw Paw protocols under the Dosage and Ease of Use (above) and Compatability (just below) sections. Some people respond very quickly to Cantron or Protocel. In this case the body may have excessive waste material to remove. Paw Paw can increase the response of your body and overload the waste removal system. To present this overload, some people start Paw Paw 3 to 5 weeks after starting Cantron or Protocel or starting Paw Paw before Cantron or Protocel.
You should avoid food for 15 minutes before and after taking Cantron or Protocel, but you should have some food with Paw Paw. therefore, people take the Cantron or Protocel first, wait 15 minutes, eat a little and take the PawPaw. New recommended doseage for Paw Paw is 2 capsule three times a day. Since the recommended dose for Cantron or Protocel is six times a day, you alternate taking Paw Paw with Cantron or Protocel with just taking Cantron or Protocel. For example:
6 AM Cantron or Protocel, 6:15 AM Paw Paw
10 AM Cantron or Protocel
2 PM Cantron or Protocel, 2:15 PM Paw Paw
6 PM Cantron or Protocel
10 PM Cantron or Protocel, 10:15 PM Paw Paw
2 AM Cantron or Protocel
Since Paw Paw is fat soluble it will work better after a person has started eating for the day. Therefore, some users start taking Paw Paw with the second dose of Cantron or Protocel. See the Dosage section just above.
Table of Contents | Return to the Comparison Table* | View Shopping Cart
Compatibility
Paw Paw reduce the side effects of chemo, but does not interfere with chemo.
Warning: If a cancer patient uses Paw Paw during a course of chemo, the reduced side effects caused by Paw Paw may encourage the oncologist to increase the dose of chemo. If the patient then decides to stop the Paw Paw, for whatever reason, the side effects of chemo can increase and greatly threaten the patients life.
One of the ways that Paw Paw works is to prevent cancer cells from feeding on glucose by reducing the ATP energy of the cells in our body. The substances in the following list increase ATP energy and should therefore be avoided when taking Paw Paw. Some people believe that you can take some of these things with Paw Paw because they were tested with Paw Paw and Paw Paw was still able to kill cancer cells in test tubes. However, Paw Paw works in a number of ways and those other ways may have been responsible for how Paw Paw worked with some of the things on this list.
Vitamins to Avoid when on Paw paw treatment
Vitamin C (taking vitamin C is the number one reason that Paw Paw fails to work)
Vitamin E
Selenium
Thyroid support products
SOD
CoEnzyme Q10
"sea greens" such as spirulina, algae, chlorella, kelp may have a problem
The amount of vitamins found in fruits and vegetables will not have a serious effect on the performance of Paw Paw.
The following counter the effects of Paw Paw:
Burdock Root Essiac tea and Flor-Essence (which is similar to Essiac with a couple of extra ingredients) Ozone treatments ( oxygen treatments such as hyperbaric oxygen are beneficial to the functioning of Protocel) Flax seed oil as used in the Budwig diet (also spelled flaxseed oil). It is starting to appear that flax seed oil may be compatible, but it remains on this list as a precaution IP6 (in theory there may be a problem, but case histories are needed) 714-x Hydrogen peroxide PMB Techno Creatine Cellect Ginseng Glutamine Taurine Rhodiola Rhosea D-Ribose Magnesium In higher doses, magnesium is credited with increasing ATP production. L-Carnitine Resveratrol Colloidal silver - the heavy metal quality of silver could cause a reaction with Protocel. Pau d'arco with Germanium-132 (taking either separately with Protocel is OK) Grapefruit seed extract (due to its high vitamin C content) Whey protein should also be avoided because of the L-cysteine Iodine IGF Enercel MSM Cesium Chloride Poly-MVA because of the alpha-lipoic acid Hormone-Blocking Drugs Immunocal MMS (Miracle Mineral Supplement) chlorine dioxide Sulfhydrazly antioxidants which includes:
L-cysteine N-acetylsteine Alpha-lipoic acid Glutathion
